We are seeking an enthusiastic and highly motivated part-time research assistant to join our group, led by Professor Michael Nicholson, to work on the transformation and modification of kidneys for transplantation. Supervised by Dr Sarah Hosgood and funded by Kidney Research UK, the post will be based in the University of Cambridge Department of Surgery at Addenbrooke's Hospital on the Cambridge Biomedical Campus (http://cambridge-biomedical.com).
About the role
In kidney transplantation, blood group compatibility is a major barrier to donor - recipient matching. Patients with more restrictive blood types like type O or B often wait twice as long for a kidney compared to patients with blood group A. Longer waiting times are associated with poorer outcome and a higher chance of patient death. To overcome this barrier, a major research theme of our group is the use of novel machine perfusion technology for the enzymatic conversion of blood group A and B kidneys to O-type. This work has already received media attention: https://www.bbc.co.uk/news/uk-62545147.
Our group has already established that bacterial enzymes can remove ABO blood group antigens from the vasculature of human kidneys. We are now exploring further concepts with the aim of bridging this basic research to a stronger position for clinical application.
Interested candidates are encouraged to read the following recent publication from our group: https://www.nature.com/articles/s41467-024-47131-9
We would like the successful candidate to support all aspects of our research, including this major theme of enzymatic blood group conversion. The role will involve assisting with the perfusion of human kidneys in a laboratory setting and undertaking the following laboratory techniques: microscopy, immunohistochemistry, immunofluorescence, image analysis, cell culture, flow cytometry, RNA extractions, ELISA and qPCR. The candidate will also be responsible for data collection/management and ordering and maintaining consumable stocks.
Candidates should have (or expect to obtain) a first or upper second-class degree in molecular or cell biology or an allied subject. Applicants with relevant research experience, gained through Master's study or while working in a laboratory, are strongly encouraged to apply. A strong background in laboratory techniques is essential.
